Cellular Senescence in Idiopathic Pulmonary Fibrosis
WEBIn this review, we will discuss our current understanding of cellular senescence, its role in age-associated diseases, with a specific focus on IPF, and potential for senotherapeutics in the treatment of fibrotic lung diseases.
Cellular Senescence in Idiopathic Pulmonary Fibrosis
WEBAug 12, 2021 · Increased senescence burden diminishes tissue resilience through cell cycle arrest as well as through SASP-induced stem cell and parenchymal cell dysfunction. As SC burden progressively increases, an additional wave of SC is generated, increasing SC burden further and further amplify AAD development and progression.
Biomarkers of cellular senescence in idiopathic pulmonary fibrosis
WEBApr 7, 2023 · Abstract. Background: Cellular senescence is a cell fate in response to diverse forms of age-related damage and stress that has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The associations between circulating levels of candidate senescence biomarkers and disease outcomes have not been specifically studied in IPF.
Cellular senescence mediates fibrotic pulmonary disease
WEBFeb 23, 2017 · Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence markers are detectable within...
Advances in cellular senescence in idiopathic pulmonary fibrosis ...
WEBFeb 15, 2023 · A better understanding of cellular senescence lung fibrosis may provide novel therapeutic strategies for the prevention and treatment of aging-related PF. Experiments have focused on the characteristics and signaling pathways of aging, but the current results are limited. Most research studies are in their early stages.
Biomarkers of cellular senescence in idiopathic pulmonary fibrosis
WEBApr 7, 2023 · Cellular senescence is a cell fate in response to diverse forms of age-related damage and stress that has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The associations between circulating levels of candidate senescence biomarkers and disease outcomes have not been specifically studied in IPF.
Advances in cellular senescence in idiopathic pulmonary fibrosis ...
WEBFeb 15, 2023 · The present review focus on senescence of LFs and epithelial and stem cells, as well as SASP, the activation of profibrotic signaling pathways and potential treatments for pathogenesis of IPF.
WEBOne of the increasingly recognized drivers for AADs is cellular senescence (CS), defined as stress-induced, non-reversible cell cycle arrest, which depletes regenerative capa-bility and is associated with release of pro-inflammatory me-diators.
Senescent lung-resident mesenchymal stem cells drive pulmonary ...
WEB6 days ago · Background Idiopathic pulmonary fibrosis (IPF) is an age-related disease featured with abnormal fibrotic response and compromised lung function. Cellular senescence is now considered as an essential driving mechanism for IPF. Given the poor knowledge of the mechanisms underpinning IPF progression, understanding the cellular processes and molecular pathways is critical for developing effective ...
Cell senescence and fibrotic lung diseases - ScienceDirect
WEBApr 1, 2020 · Cellular senescence, a permanent arrest of cell growth, has been increasingly recognized as an important contributor to aging and aging-related diseases, including IPF. Senescent cells have been identified in IPF …
- Some results have been removed