Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis …
WEBJul 10, 2024 · These results demonstrate the multifaceted roles of the alveolar fibroblast lineage in maintaining normal alveolar homeostasis and orchestrating sequential responses to lung injury.
Acute alveolar injury and repair - PMC - National Center for ...
WEBMar 2, 2011 · Intra-alveolar and obliterative pulmonary fibrosis have many causes in common. The pattern of fibrosis depends not so much on the nature of the damage as its severity. With very severe injury the alveolar lumen is flooded with a fibrin-rich exudate, organisation of which completely obliterates the air spaces over broad tracts of lung.
Mechanisms of alveolar epithelial injury, repair, and fibrosis
WEBProgressive fibrosis and cancer may therefore represent the extremes of a highly dysregulated tissue injury response. This brief review focuses on some of this evidence and on our current understanding of abnormal tissue repair responses after chronic epithelial injury in the specific context of IPF.
Mechanisms of Alveolar Epithelial Injury, Repair, and Fibrosis
WEBThe challenge facing many fibrotic lung diseases is that these conditions usually present late, often after several decades of repetitive alveolar epithelial injury, during which functional alveolar units are gradually obliterated and replaced with nonfunctional connective tissue.
Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in ...
WEBMar 25, 2020 · Alveolar epithelial type II cells (AT2) functions in lung fibrosis. An overview schematic illustration described functional roles of AT2 cells to maintain lung homeostasis during injuries and their profibrotic phenotypic changes that promote lung fibrosis upon the presence of risk factors e.g., aging, environmental stress, etc.
Targeting Alveolar Repair in Idiopathic Pulmonary Fibrosis
WEBMar 30, 2021 · This review will describe the current knowledge of reparative epithelial progenitor cells in the alveolar region of the lung and discuss potential novel therapeutic approaches for IPF, focusing on endogenous alveolar repair. Keywords: epithelium, lung, regeneration, stem cells.
Progressive Pulmonary Fibrosis Is Caused by Elevated ... - Cell …
WEBHere we establish a direct mechanistic link between elevated mechanical tension caused by impaired alveolar regeneration and progressive lung fibrosis, illuminating a pathogenic mechanism that may underlie fibrosis more generally.
Repair and regeneration of the alveolar epithelium in lung injury
WEBApr 22, 2024 · Alveolar epithelial cells are surrounded by various cells, such as fibroblasts, endothelial cells, and various immune cells, which affect the proliferation and differentiation of AT2 cells through paracrine during alveolar regeneration. Besides, airway epithelial cells also contribute to the repair and regeneration process of alveolar epithelium.
Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis …
WEBAbstract. Fibroblasts are present throughout the body and function to maintain tissue homeostasis. Recent studies have identified diverse fibroblast subsets in healthy and injured tissues 1,2, but the origins and functional roles of …
Cell Cross-Talk in Alveolar Microenvironment: From Lung Injury to Fibrosis
WEBAlveoli are complex microenvironments composed of various cell types, including epithelial, fibroblast, endothelial, and immune cells, which work together to maintain a delicate balance in the lung environment, ensuring proper growth, development, and …
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