Pulmonary Arterial Hypertension: Pathophysiology and …
WEBMay 16, 2018 · Pulmonary hypertension (PH) consists of a group of diseases with a resting mean pulmonary artery pressure (mPAP) ≥ 25 mmHg as measured with right heart catheterization . Since 1998, major revisions in the classification of PH have categorised the disease based on the anatomical site and aetiology.
Pulmonary Hypertension - StatPearls - NCBI Bookshelf
WEBMay 1, 2024 · Systemic diseases that can cause pulmonary hypertension include pulmonary Langerhans cell histiocytosis, neurofibromatosis type 1, and sarcoidosis. Glycogen storage diseases and Gaucher disease are metabolic disorders that can cause pulmonary hypertension.
State of the Art Review: Pulmonary arterial hypertension: pathogenesis …
WEBMar 14, 2018 · However, these vasodilators do not target key features of PAH pathogenesis and have not been shown to reduce mortality, which remains about 50% at five years. This review summarizes the epidemiology, pathogenesis, diagnosis, and treatment of PAH.
New Mutations and Pathogenesis of Pulmonary Hypertension: …
WEBApr 29, 2022 · Pulmonary arterial hypertension (PAH) is a complex multifactorial disease with poor prognosis characterized by functional and structural alterations of the pulmonary circulation causing marked increase in pulmonary vascular resistance, ultimately leading to right heart failure and death.
Revised Definition of Pulmonary Hypertension and Approach to …
WEBApr 7, 2023 · In patients with mPAP of 20 to 25 mm Hg and PVR of 2 to 3 WU, the focus of clinical management includes clarifying causes of mild PH, risk factor modification, close follow‐up for symptom progression, and consideration to clinical trial enrollment.
Pulmonary Arterial Hypertension | New England Journal of …
WEBDec 15, 2021 · Without effective treatment, pulmonary arterial hypertension results in high morbidity and mortality. This review discusses the pathogenesis of the disorder, the thorough clinical evaluation...
Classification and pathophysiology of pulmonary hypertension
WEBJul 27, 2018 · Common pathogenic features of pulmonary hypertension include sustained pulmonary vasoconstriction, vascular remodeling of the small pulmonary arteries, in situ thrombosis, and increased vascular wall stiffness, resulting in increased pulmonary arterial pressure due to increased pulmonary vascular resistance.
Pulmonary Hypertension - Pulmonary Hypertension - The …
WEBKey Points. Pulmonary hypertension is increased pressure in the pulmonary circulation. It has many secondary causes; some cases are idiopathic. In pulmonary hypertension, pulmonary vessels may become constricted, pruned, lost, and/or obstructed. Severe pulmonary hypertension leads to right ventricular overload and failure.
The epidemiology and pathogenesis of pulmonary arterial hypertension …
WEBApr 4, 2024 · The World Health Organization (WHO) classifies patients with PH into five groups (table 1) based upon etiology [1]: Group 1 – Pulmonary arterial hypertension (PAH) Group 2 – PH due to left heart disease. Group 3 – PH due to chronic lung disease and/or hypoxemia.
Pulmonary hypertension | Nature Reviews Disease Primers
WEBJan 4, 2024 · This Primer reviews the epidemiology and pathophysiology of pulmonary hypertension, discusses diagnosis and management, and provides an overview of current open research questions.