Oct 17, 2025; Miami Gardens, Florida, USA; Louisville Cardinals running back Isaac Brown (1) carries the football against Miami Hurricanes linebacker Mohamed Toure (1) and linebacker Wesley Bissainthe (31) during the first quarter at Hard Rock Stadium. Mandatory Credit: Sam Navarro-Imagn Images / Sam Navarro-Imagn Images

Preview the Oct. 25 matchup between the Louisville Cardinals and Boston College Eagles with predictions, odds, over/under, spread, betting lines and more.

I implore you to look up the definition of insanity, but we march on slowly, mercilessly. Grayson James will lead the way again for a still-hobbled Eagles team. Last time BC won in Louisville was the AJ Dillon has arrived game.

Louisville returns home after picking up one of its biggest wins in school history, knocking off No. 2 Miami 24-21 at Hard Rock Stadium on Friday night. It was the school’s seco

Jeff Brohm is 0-5 in games immediately after a top-10 win. Can Louisville, fresh off an upset at Miami, avoid a loss against Boston College?