Reduced levels of a critical protein are linked to devastating brain diseases like Alzheimer's, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS). Surprisingly, the protein shortage ...

Amyotrophic lateral sclerosis (ALS), the most common ... where misfolded proteins propagate by inducing similar misfolding in normal proteins. Understanding these mechanisms opens new avenues ...

Owing to the heterogeneous nature of amyotrophic lateral sclerosis (ALS), panels of protein biomarkers derived from cerebrospinal fluid and blood may be most valuable for generating an accurate ...

A toxic version of a certain protein may affect brain, spinal cord and skeletal muscle tissues differently, leading to the complex development and progression of amyotrophic lateral sclerosis (ALS ...

Researchers at Goethe University, Johannes Gutenberg University Mainz and Kiel University discover possible method for preventing protein aggregates – Cluster4Future PROXIDRUGS research project.

Scientists say they have discovered how a group of proteins linked to Parkinson's disease and amyotrophic lateral sclerosis act as 'guardians' of mitochondria, small organelles, or subunits ...

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease ... which it uses to cut itself and the gag form into pieces. Using a combination of protein biochemistry and cell ...

Reduced levels of a critical protein are linked to devastating brain diseases like Alzheimer's, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS). Surprisingly, the protein shortage ...

Gain’s focus is on LSDs that are caused by proteins that ... dementia and amyotrophic lateral sclerosis (ALS), whilst other players include Orphazyme, Prothena and Proclara.

Bruening, W. et al. Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis. J. Neurochem ...

and Amyotrophic Lateral Sclerosis (ALS). The major focus of our studies has been the identification of the cellular and molecular mechanisms by which specific proteins central to these diseases (e.g., ...