Analgesics are medications that relieve pain. They work either by reducing inflammation or by changing the way the brain processes and perceives pain. Side effects include heartburn, nausea, and ...

Researchers at Scripps Research have redesigned fentanyl at the molecular level, challenging decades-old assumptions about opioid chemistry.

Pain management is an inexact science; there is plenty of blame to go around for the abuse of such drugs. To the Editor: Re “The D.E.A. Should Get Out of Public Health,” by Shravani Durbhakula ...

Opioids are drugs that people use to treat pain and certain other complaints. Opioids can derive from natural sources, and people can make them synthetically. There are several types of opioids ...

The Food and Drug Administration’s latest plan to study whether opioids are effective as a chronic pain treatment is facing significant resistance from addiction and pain care experts. A planned ...

Scripps Research scientists have re-engineered fentanyl’s core structure to retain potent analgesia while limiting respiratory depression in preclinical tests – a strategy that could inform ...

New research has identified an alternative signaling pathway in the brain of mice that relieves pain, even in animals that have developed tolerance to opioids. The study also showed that pain relief ...

Koumine, a prominent monoterpene indole alkaloid isolated from Gelsemium elegans, has emerged as a compound of considerable interest due to its multifaceted pharmacological profile. Extensive ...

Opioid-induced bowel dysfunction (OIBD) is a group of gastrointestinal symptoms that arise from the prolonged use of opioid analgesics. The treatment options available for it are limited in their ...