The apoptosis pathway is closely related to the Bcl-2 family proteins in which antiapoptotic members sequester multidomain proapoptotic proteins, thereby inhibiting their active role in apoptosis. In ...
Common belief has held that in Alzheimer disease, buildup of neurofibrillary tangles within neurons switches on caspases that eventually kill the cells. However, an analysis published March 31 in ...
Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...
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