“[It] suggests that chromatin is a sticking point preventing artificially induced reprogramming [from] being used routinely in the clinic." For the experiment, Gurdon and colleagues implanted a ...

Northwestern Medicine scientists have uncovered new details about the genetic structure of ovarian cancer stem cells, ...

Reprogramming also refers to the erasure and ... Ubiquitin-specific peptidase 22 (USP22) is identified as a key chromatin-based barrier to human iPSC derivation through a chromatin-focused CRISPR ...

The scientists observed that chromatin self-organizes into "packing ... and promoting longevity by developing strategies to preserve or even reprogram these transcriptional memories," Backman ...