Research published in Cell Research from Mario Halic, PhD, St. Jude Department of Structural Biology, revealed 13 distinct ...

Reconstitution with purified components will reveal the biochemical pathways, the particular histone modifications and the multiple chromatin states involved. The results will ultimately be ...

Northwestern Medicine scientists have uncovered new details about the genetic structure of ovarian cancer stem cells, ...

Approximately 50% of chromosomes and chromatin is protein. These include histones, transcription factors, nuclear receptors, co-activators, co-repressors, histone modifying enzymes, nucleosome binding ...

Further, although “chromatin precipitation has been important in establishing which components reside in a structure, it has temporarily blinded us to the dynamics” 1. It is indeed easy to ...

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how ...