Cells use many complex genetic repair backup systems to fix DNA damage and remain healthy throughout their lives.

They constantly untangle knots in the DNA strand and create new chemical bonds when a strand of DNA breaks somewhere in the nucleus ... Professor of Genome Biology at ETH Zurich. However, repair ...

This process mends breaks ... mutated DNA repair genes to assess a person’s risk of related cancers. Dynamic single-molecule analysis revealed that the BRCA2 protein binds to double stranded ...

A research team has unveiled a crucial mechanism that helps regulate DNA damage repair, with important implications for ...

A few years ago, the advent of technology known as CRISPR was a major breakthrough in the scientific world. Developed from a ...

In this Review, familial and sporadic neurological disorders reported to have an etiological link with DNA repair ... excision repair; pol η, polymerase η; SSB, single-strand break; TCR ...

Recent efforts in our lab have focused on complexes mediating DNA double strand break (DSB) repair. These range from the Structure Maintenance of Chromosome Smc5/6 complex involved in rescue of ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

The native structure of genomic DNA can be damaged in many ... nucleotide excision repair; pol η, polymerase η; SSB, single-strand break; TCR, transcription-coupled repair.