The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?

Due to their activation by growth factors ... All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired. Journal of Biological Chemistry 271, 5251–5257 ...

Lipids in cell membranes regulate the activity of a cancer-linked protein, cell biologists at RIKEN have discovered. This ...

Bicara Therapeutics shows potential to reshape cancer care with ficerafusp alfa and robust funding post-IPO. Find out why ...

CytomX Therapeutics, Inc.’s CTMX share price has surged by 6.39%, which has investors questioning if this is right time to ...

and epidermal growth factor (EGF). Fibrogenesis. Increased matrix production is the most direct way that stellate cell activation generates hepatic fibrosis. The most potent stimulus to collagen I ...

Although many ecDNA-encoded oncogenes and their protein products, such as epidermal growth factor receptor (EGFR ... of telomeric length, or the activation of an oncogene can lead to genome ...

Apollomics and LaunXP have signed an agreement to develop and commercialise the former’s c-Met inhibitor vebreltinib combined with an epidermal growth factor receptor inhibitor (EGFRi ...

We explore the translational potential for various CARs under active investigation, including human epidermal growth factor receptor 2–directed CARs in breast cancer, prostate stem cell ...