X inactivation turns off entire chromosomes, whereas imprinting turns off only specific genes. How do these processes work, and why do they often produce similar results? Upon examining their ...

You're not an equal product of both parents' genes. Genomic imprinting, a process whereby only one gene copy is expressed, not only exists but, combined with mutations, may lead to disease.

Not only are alleles inherited from a mouse’s mom or dad expressed in unequal proportions in various cells in the brain and adrenal system—a phenomenon called genomic imprinting—but expressing the ...

A key focus of the research is the success in identifying differences between the two alleles and, in some cases, demonstrating that these differences result from genomic imprinting—meaning that ...

Mammalian reproduction involves genomic imprinting, a process in which epigenetic modifications restrict the expression of certain genes to a single parental allele. The genes that are silenced or ...

A well-studied DNA methylation-based phenomenon is genomic imprinting (ie, genotype-independent parent-of-origin effects). Objective We aimed to elucidate: (1) the effect of exercise on DNA ...

the associated genes are only missing from the father’s side of the genetic equation. Individuals with PWS still carry the requisite genes from the mother, but in healthy individuals, those genes are ...

pregnancy loss with multi-locus imprinting abnormalities, and offspring with birth defects3,4. We also work on identifying and characterizing the genetic defects that cause X-linked dominant ...

Researchers have developed a comprehensive atlas that maps DNA methylation—a critical chemical modification governing gene activity—across 39 human cell types, revealing a complex landscape of ...