Cells are incredibly adept at creating complex molecules, like therapeutics, and can do so much better than many of our best factories. Synthetic biologists look to re-engineer cells to make these ...

Statins are a class of fungal secondary metabolites that inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. Filamentous fungi, notably Aspergillus terreus, Penicillium ...

The raw material for de novo fatty acid synthesis is acetyl-CoA, which can be obtained via the citrate shuttle pathway or from acetic acid. ACC and FASN catalyze the conversion of acetyl-CoA into ...