Chemical changes to histones, the proteins that help to pack and organize DNA inside cells, play a key role in determining what genes will be consistently activated over the course of an animal or ...
A new review maps how the histone lactylation mark H3K18la links lactate metabolism to gene control, driving both disease ...
Key modifications involved in HCC include lysine methylation and acetylation, regulated by KMTs/KDMs and HATs/HDACs, respectively, which influence chromatin accessibility and transcriptional activity.
Plant DNA viruses — including double-stranded DNA viruses such as caulimoviruses and single-stranded DNA viruses such as ...
Every cell type in the human body carries the same approximately 3.2 billion base pairs of DNA, yet a liver cell behaves nothing like a neuron. The epigenome explains this difference: in each cell, ...
A review finds that protein modifications regulate immune inflammation and epithelial barrier dysfunction in ulcerative ...
The serine 31 (Ser31) phosphorylation modification (H3.3S31ph) in the N-terminal tail of the histone variant H3.3 can transform H3.3 nucleosomes from a stable state to a dynamically activated ...
A molecular model showing three of the main epigenetic modifications of DNA (orange) and histones (dark blue) [JUAN GAERTNER/Science Photo Library/Getty Images] Post-translational modifications (PTMs) ...
A research team from AIST, the Institute of Science Tokyo, and Ritsumeikan University has demonstrated that the phase behavior of histone–DNA condensates depends on the site of histone acetylation.
The central dogma of molecular biology has expanded well beyond the flow of information from DNA-to-RNA-to-protein into a system of complex interactions and feedback loops among all these ...
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