Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Both ends can be simply rejoined with little or no further processing (nonhomologous end joining, or NHEJ) or can be repaired using homologous sequences (red DNA; homologous recombination ...

The team showed that blocking homologous recombination changed the way the ... radiotherapy depends on the engagement of ...

When recombination occurs during meiosis, the cell's homologous chromosomes line ... in eukaryotes because it can be used to help repair broken DNA, even when the break involves both strands ...

Northwestern Medicine investigators have discovered new molecular mechanisms underlying DNA repair dysregulation ... but they're only used in homologous recombination deficient cancer types ...

QIAGEN N.V. (NYSE: QGEN; Frankfurt Prime Standard: QIA) today announced a series of product and partnership updates designed ...

It is thought that these flanking segments mediate the binding of mammalian DNA ligases to other proteins involved in DNA replication, repair, and recombination ... repair of double-strand DNA breaks ...

These three-stranded nucleic acid structures, composed of an RNA:DNA hybrid and a displaced ... and facilitating repair through homologous recombination. However, when dysregulated, R-loops ...