Single-cell analysis revealed the molecular triggers that drive stem cells to become cancerous, which may help inform early-stage treatments. New methods for deriving macrophages from induced ...

In vivo, the intestinal epithelium interacts with the neighboring ... New methods for deriving macrophages from induced pluripotent stem cells are easier to scale and provide more clinically relevant ...

It is unclear which intestinal epithelial cell-derived cytokines can precisely regulate intestinal stem cell (ISC) commitment toward specific mature cells. Here, authors identify an epithelial ...

difficile infection. The white areas show the cells that line the intestine (epithelial cells). In red is the MHC-II protein, which helps activate the immune system, and in blue is the nucleus of ...

More information: Alison R. S. Pashos et al, H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium, Nature Cell Biology (2025). DOI: 10.1038/s41556-024-01580-y ...

difficile infection. The white areas show the cells that line the intestine (epithelial cells). In red is the MHC-II protein, which helps activate the immune system, and in blue is the nucleus of ...

Fachi et al, Fiber- and acetate-mediated modulation of MHC-II expression on intestinal epithelium protects from Clostridioides difficile infection, Cell Host & Microbe (2025). DOI: 10.1016/j.chom.