"Lipid Expansion Microscopy" published in the Journal of the American Chemical Society on October 3, a few days before Baskin's related doctoral research appeared in the chemistry Nobel Prize ...

Establishing relationships between lipid chemistry and immune response is necessary in order to expand the use of lipid nanoparticles beyond RNA vaccines. Cells in the body have receptors that detect ...

Nanoparticle coatings can come loose in the body, causing therapies to miss their target or trigger side effects. The development and subsequent approval of SARS-CoV-2 mRNA vaccines saved countless ...

Lipid membranes are self-assembled bilayers composed primarily of amphipathic lipids such as phospholipids, cholesterol and glycolipids. These structures form the fundamental barrier and functional ...

Therapeutics that use mRNA - like some of the COVID-19 vaccines - have enormous potential for the prevention and treatment of many diseases. These therapeutics work by shuttling mRNA 'instructions' ...

Postdoctoral fellow and co-first author Dongyoon Kim demonstrates some of the equipment used to craft the new ionizable lipids. [Bella Ciervo, Penn Engineering] The explosion of mRNA vaccines brought ...

Figure 1. A schematic representation of a lipid nanoparticle encapsulating mRNA. As this new form of biotechnology makes a leap of progress, so too do the analytical approaches supporting its ...

The most common side effects of mRNA vaccines like the COVID-19 shot are well known: soreness, mild fever and general malaise. Those symptoms, which typically resolve within days, are the natural ...

Lipids are fatty compounds that perform a range of essential functions in the body. Phospholipids, steroids, and triglycerides are examples of lipids. Although lipids play an essential role in the ...

James Parkinson, a 19th-century British surgeon, first reported what he called “the shaking palsy” in 1817, after observing a handful of patients with tremors and difficulty moving. More than 200 ...