Use of the long-acting insulin analogs glargine and detemir does not reduce the risk of diabetic ketoacidosis in children and adolescents with type 1 diabetes mellitus (T1DM), compared with the ...

In an awake individual, mild-to-moderate nocturnal hypoglycemia is easily corrected by ingesting a snack containing approximately 5 g of fast-acting carbohydrate ... the basal insulin, a bedtime ...

To mimic physiological insulin release, both long-acting and short-acting insulin preparations are needed. After decades of optimizations to develop longer-acting insulin preparations to reduce ...