Lysosomes are dynamic organelles that receive membrane traffic input from the secretory, endocytic, autophagic and phagocytic pathways. They can also fuse with the plasma membrane. Live-cell imaging ...

What do cells do when they are “hungry”? Eukaryotic cells cope with starving conditions by eating their own components, a process called autophagy. Aa Aa Aa Normally, when you are hungry you look for ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes. Lysosomes ...

Long recognized as the cell’s recycling depot, a new study has found lysosomes act as signaling hubs that coordinate metabolism and longevity by communicating signals across tissues. According to a ...

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the ...

Mutations in the progranulin gene cause a form of frontotemporal dementia, most likely because levels of the protein fall in the central nervous system. How this affects brain function is unknown.

Salmonella enterica is an intracellular bacterial pathogen that replicates within membrane-bound vacuoles through the action of effector proteins translocated into host cells. Salmonella vacuoles have ...

In neurodegenerative diseases, misfolded proteins pile up. Previous studies have pointed an accusing finger at faulty lysosomal garbage disposal systems and now, new evidence from several groups ...

Neonatal intestinal disorders that prevent infants from getting the nutrients they need may be caused by defects in the lysosomal system -- or cell recycling center -- that occur before weaning.

Glutamate, a key neurotransmitter involved in brain function, plays a crucial role in processes such as mood regulation and memory formation. However, research has also linked glutamate to the toxic ...

'Miniature shredders' are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to ...