Multiple acyl-CoA dehydrogenase deficiency (MADD) and related lipid storage myopathies comprise a heterogeneous group of inherited metabolic disorders that impair fatty acid oxidation and cellular ...
Mitochondrial DNA (mtDNA) mutations impair OXPHOS and enhance lactate accumulation in skeletal muscle. Elevated lactate drives H3K14 histone lactylation, inducing GDF15 expression and secretion in ...
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