Prior animal research showed an association between the neuropeptide Y (NPY) pathway and its three receptor genes and alcohol dependence (AD), alcohol withdrawal, and cocaine use. New human findings ...

A peripherally acting substance that boosts energy expenditure and reduces fat mass has the potential to become an obesity treatment that doesn't produce cardiovascular or psychiatric side effects, ...

Feeding in mammals is controlled by a complex neural system. Although several key neural pathways related to total calorie ...

Hypertension is an independent determinant of cardiovascular risk, a phenotype that usually has a strong genetic component. Neuropeptide Y (NPY) plays an important role in BP homeostasis. The aim of ...

Neuropeptide Y exhibits neuroprotective effects. Whether the neuroprotective effects are mediated by the pathways including regulating the immunological activity of reactive microglia and reducing ...

Experiences of early life stress are more prevalent among depressed patients than healthy controls. Neuropeptide Y (NPY) was suggested to play a role in the pathophysiology of depression. Consequently ...

Researchers found that lung immune cells (phagocytes) produce increased levels of neuropeptide Y (NPY) when mice are infected with severe influenza virus. NPY and its receptor form the NPY-Y1R axis.

Two recent papers tap an old hand and a relative newcomer as potential Alzheimer disease therapies—both are peptides but they have very different resumes. In the February 2 PNAS online, researchers ...

Objective: Elevated triglyceride (TG) is the major plasma lipid abnormality in obese and diabetic patients and contributes to cardiovascular morbidity in these disorders. We sought to identify novel ...

Obesity is a major public health concern with over 10% obese people globally. Each year, millions of people die from obesity related diseases, such as diabetes and cardiovascular disease. Neuropeptide ...

Pancreatic cancer is still among the most lethal cancers, with >45% of patients presenting distant metastasis at diagnosis, and with a 5-year survival rate of 13%. Known for its role in appetite and ...

Prior animal research showed an association between the neuropeptide Y (NPY) pathway and its three receptor genes and alcohol dependence, alcohol withdrawal and cocaine use. New human findings link ...