Depression and anxiety disorders arise from complex disturbances in brain chemical signalling. Key monoamine neurotransmitters—serotonin, noradrenaline and dopamine—regulate mood, motivation and ...

Major depressive disorder is characterised by altered brain structure, connectivity and chemical signalling. Neuroimaging modalities have elucidated structural atrophy in prefrontal and limbic regions ...

For many years, depression has been viewed mainly as a disorder involving brain chemicals. Most commonly prescribed ...

In the intricate chemical symphony of the brain, glutamate stands as the principal conductor. As the brain's most abundant excitatory neurotransmitter, glutamate facilitates our ability to learn, form ...

Dealing with mental health conditions like depression can be challenging. Some people struggle to find the right treatment or combination of treatments for their condition. In major depression ...

A collage of a ball-and-stick model of a serotonin molecule, a sad-looking person, some drug capsules, and a brain Credit: Shutterstock/Madeline Monroe/C&EN For decades, doctors, neuroscientists, and ...

A recent clinical trial suggests that treating the immune system with an anti-inflammatory drug could relieve symptoms in ...

Depression is a complex and deeply personal experience. While almost everyone has periods of sadness, low mood or grief, depression is different. Major depressive disorder is persistent, interferes ...

Alzheimer’s disease and late-life depression produce markedly different patterns of brain shrinkage and chemical disruption, ...

Now, a new study using nationally representative U.S. data found that adults with adequate levels of several key micronutrients (including vitamin D, iron, selenium, copper, and vitamin B6) were less ...

Discover how high-functioning depression hides behind success, masking emotional distress and delaying timely support ...