Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements.

The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that ...

Role of RANKL in differentiation, fusion, activation and survival of osteoclasts. Osteoclast differentiation is a multistep process. Myeloid progenitor cells progressively differentiate into ...

Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements.

Using OPG-deficient mice as a useful animal model, we attempted to clarify differentiation and ultrastructural features of osteoclasts located on destructed growth plate cartilage and trabecular bone ...

A recent study by TUS researchers reveal that the Cpeb4 protein may have a role in regulating osteoclast differentiation. This, in turn, could lead to the development of new therapeutic drugs for ...

Osteoblasts/stromal cells produce osteoclast differentiation factor (ODF) or stromal osteoclast forming activity (SOFA) as a membrane-associated factor in response to osteotropic factors ...

Excessive osteoclast activity can lead to increased bone resorption, which contributes to osteoporosis. The findings revealed that iSN40 completely inhibits the differentiation of osteoclast ...

This ligand and M-CSF are now known to be essential for osteoclast differentiation from marrow and circulating precursors. This study examined whether OPGL and its soluble receptor osteoprotegerin ...