Genetics play a role in low testosterone for some men, but underlying causes vary widely. Many genes influence testosterone ...

Imagine the deep frustration of countless men who long to become fathers, only to face infertility due to a genetic condition they can't control. For those with Klinefelter syndrome, this painful ...

Testosterone replacement therapy (TRT) reduces mortality risk by nearly 50% in men with Klinefelter syndrome (KS), bringing their survival rates closer to those of men from the general population. Men ...

SMALL testes and aspermia are both characteristic features of Klinefelter's syndrome, and histological examination of the testes usually shows a lack of active spermatogenesis. Biopsies on testes ...

Researchers at the University of Colorado Anschutz Medical Campus and collaborators across the country have conducted the largest and most diverse study of men with extra X or Y chromosomes in the US ...

Men with Klinefelter syndrome (KS) showed an increased risk for metabolic conditions such as type 2 diabetes (T2D) and obesity-related disorders, regardless of diagnosis and treatment status.

THE tubules in the adult testis are characteristically totally hyalinized in Klinefelter's syndrome. But non-hyalinized tubules are often found in biopsies of reasonable size. Spermatogenesis may ...