Abstract Rare and common genetic variants contribute to the risk of atrial fibrillation (AF). Although ion channels were among the first AF candidate genes identified, rare loss-of-function variants ...

Titin is responsible for making muscle stretchy and bendy. But a mutation in the TTN gene (which makes the titin protein) can cause the heart to fail because it causes the heart muscle to become ...

Assessment of respiratory muscle function in mouse models of muscular dystrophy A complex rearrangement mutation in the mouse titin gene leads to an in-frame 83-amino acid deletion in the N2A region ...