Among the explanations offered for tau’s detrimental effects on neurons in Alzheimer disease is that elevations in tau levels, and/or changes in its cellular distribution, disrupt microtubule function ...

Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known ...

You can’t keep a good mitochondrion down. Or maybe you can. In today’s Cell, researchers led by Zu-Hang Sheng at the National Institute for Neurological Disorders and Stroke report that the protein ...

What Makes a Good Potential Target for Drug Discovery? Listen in as Dr Elizabeth Glennon, of King's College London, discusses how the disruption of axonal transports early on within Alzheimer's ...

Schematic representation of axonal transport vesicles (blue) carrying presynaptic proteins (SV and AZ proteins). Kinesin motor proteins (KIF1A) attach these vesicles and carry them along the axons to ...

Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...

This is a preview. Log in through your library . Abstract KIF1A is a kinesin superfamily motor protein that transports synaptic vesicle precursors in axons. Cargo binding stimulates the dimerization ...

This is a preview. Log in through your library . Abstract βII-spectrin is the generally expressed member of the β-spectrin family of elongated polypeptides that form micrometer-scale networks ...

Huntington's disease is a genetic neurodegenerative disorder caused by mutations in the protein huntingtin and characterized by involuntary dance-like movements, severe behavioural changes and ...