The clonidine skin patch may cause a rash. Continuing to use it, or switching to the oral version, may trigger an allergic reaction. To relieve dry mouth, chew gum or suck sugarless hard candy.

Dermatitis. 2006;17(3):109-122. In 1985, Maibach reported a series of trials performed to determine both the irritation and sensitization potential of clonidine and clonidine TTSs. The irritation ...

Clonidine 0.1mg/day, 0.2mg/day ... If local reaction occurs from patch, using tabs may cause generalized rash. Discontinue 4hrs before surgery; resume as soon as possible after surgery.