Chronic kidney disease (CKD) affects >850 million people globally and is an important risk factor for cardiovascular disease ...

BACKGROUND: An interatrial shunt may provide an autoregulatory mechanism to decrease left atrial pressure and improve heart failure (HF) symptoms and prognosis. METHODS: Patients with symptomatic HF ...

People who experience out-of-hospital cardiac arrest often require care at a regional center for continued treatment after ...

Early identification of kidney dysfunction in patients with advanced heart failure is crucial for timely interventions. In ...

To achieve cardiovascular health (CVH) equity in the United States, an understanding of the social and structural factors that contribute to differences and disparities in health is necessary. The ...

Arterial thrombosis is a dynamic process triggered by contact of the blood with an injured blood vessel wall or a medical ...

BACKGROUND: The docking protein IRS2 (insulin receptor substrate protein-2) is an important mediator of insulin signaling and ...

BACKGROUND: Endothelial cells (ECs) use glycolysis to produce energy. In preclinical models of peripheral arterial disease, further activation of EC glycolysis was ineffective or deleterious in ...

BACKGROUND: The European Chronic Thromboembolic Pulmonary Hypertension registry (CTEPH), conducted between 2007 and 2012, reported the major impact of pulmonary endarterectomy (PEA) on the long-term ...

BACKGROUND: Cardiac troponin (cTn) is key in diagnosing myocardial infarction (MI). After MI, the clinically observed half-life of cTn has been reported to be 7 to 20 hours, but this estimate reflects ...

Cardiovascular Institute (X.Z., T.W., Y.G., J.A.E., Y.F.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Department of Radiation Oncology (X ...

Cardiac hypertrophy and its associated remodeling are among the leading causes of heart failure. Lysine crotonylation is a recently discovered posttranslational modification whose role in cardiac ...