On Wednesday, Aileron Therapeutics Inc (NASDAQ; ALRN) revealed topline data from Cohort 2 of its Phase 1b trial of safety and ...

High-dose LTI-03 (5 mg BID), a Caveolin-1 related peptide, reduced expression of multiple profibrotic proteins in both pathological basal-like cells and fibroblasts and decreased the expression of a ...

Identifying the underlying causes of prolonged lung inflammation associated with radiographic abnormalities could be key understanding long COVID and other lung conditions, researchers say.

A new study demonstrates how AlveoliX’ Lung-on-Chip model offers a more accurate and predictive approach to investigating respiratory diseases and testing potential treatments. AMYRA successfully ...

What is cystic fibrosis liver disease? Liver disease associated with cystic fibrosis (CF) has been increasingly diagnosed during recent years, most likely due to the combined effect of systematic ...

6). There was marked interalveolar fibrosis, and the alveolar walls blended with the interstitial fibrous tissue. Giant-cell reaction to the concretions was present, most of the giant cells being ...

In the first 2 weeks after bleomycin exposure, the mice develop alveolar as well as interstitial fibrosis (Peng et al., 2013). Gene expression at days 1 or 2 (inflammation); 7 or 14 (acute fibrosis) ...

These cells include alveolar type 2 (AT2 ... model will enable studying the basic causes of diseases like pulmonary fibrosis, as well as the testing of potential new drugs, according to the ...

Moreover, the severity of CT scan changes correlated with the abundance of neutrophils and a type of macrophage called monocyte-derived alveolar macrophage, or MoAM. A higher abundance of MoAMs ...

The authors first showed that patients with idiopathic PF or bleomycin-treated wild-type mice express more citrullinated histone H3 (citH3) than controls. This observation aligns with studies citing ...

Pulmonary fibrosis, including its most common form ... epithelial cells initiate and perpetuate the disease, including alveolar type 2 (AT2) cells, which are responsible for maintaining the ...