Albumin binding to FcRn, GP60, and SPARC results in an improved PK profile, decreased toxicity risk, and a broader therapeutic index preclinically, with significant targeting of the tumor ...

(B) Describes the proposed mechanism of uptake of HMCD-drug conjugates into tumor cells. Albumin-bound HMCDs bind to caveloin-1 associated Gp60 receptors, triggering caveolae-mediated transcytosis ...

Martha graduated from University of Cambridge with a BA in Natural Sciences and went on to do a PhD in cell biology at University College London. She then undertook postdoctoral work at Massachusetts ...