Blood clots can lead to thigh pain. Deep vein thrombosis, or DVT, most often occurs in the lower leg, thigh, or pelvis. Poor blood flow also can contribute to nerve injury and damage that can affect ...

Most causes of new onset muscle weakness are serious. True weakness points to diseases of the spinal cord or its nerves. Nerves carry messages from the spinal cord to the muscles in the arms and legs.

Injuries to the leg (hip to foot) Injuries to a bone, muscle, joint or ligament Muscle pain caused by too much exercise or work (overuse). Overuse is covered in Leg Pain. Excluded: Toe Injury only.