Nucleoid-associated proteins (NAPs) bind to the bacterial chromosome and alter its dynamics, maintaining nucleoid structure. In this Review, Dillon and Dorman examine the range of proteins in the ...

Credit: 2022, Takaya Ishihara, Mitochondrial nucleoid trafficking regulated by the inner-membrane AAA-ATPase ATAD3A modulates respiratory complex formation, Proceedings of the National Academy of ...

Nucleoid remodeling is a common strategy among bacteria to protect their DNA against external stresses. This process is primarily controlled by NAPs (Nucleoid Associated Proteins), ...

“Nucleoid trafficking may represent a new therapeutic target to prevent mitochondrial dysfunction in various human diseases,” explains senior author Naotada Ishihara.

"Nucleoid trafficking may represent a new therapeutic target to prevent mitochondrial dysfunction in various human diseases," explains senior author Naotada Ishihara.

The nucleoid occupies a central position in the bacterial cell as the nucleus does in eukaryotic cells. However, unlike the nucleus, the nucleoid constantly undergoes structural changes.

Our chromosomes are much longer than the space in which they are packaged in the cell. Chromosome compaction is on the order of several thousand fold, yet these chromosomes have to be unraveled every ...

The paper, by M. Hammel at the Lawrence Berkeley National Laboratory in Berkeley, Calif., and colleagues was titled, "HU multimerization shift controls nucleoid compaction." view more Credit ...

“Nucleoid trafficking may represent a new therapeutic target to prevent mitochondrial dysfunction in various human diseases,” explains senior author Naotada Ishihara. Therefore, not only does this ...