Several students from the Southern Arkansas University College of Science and Engineering took part in the 108th annual ...

Department of Pediatrics, Columbia University, New York, NY, United States Collectively, these findings suggests that Mtb survival hinges on its ability to manipulate host macrophage metabolism. By ...

The approach pioneered by Guan's lab uses engineered particles with fluorescent markers that allow researchers to observe their breakdown and formation into phagosome-derived vesicles, or PDVs.

Recent studies have generated new insights into the mechanisms of pathogen entry into host cells and signal transduction, but very little is known about the bacterial effectors and cellular ...

"Rather than letting the bacteria continue to replicate, the mitochondria sense bacterial metabolites in the phagosome and trigger the neutrophil to undergo NETosis—an antimicrobial cell death ...

M.tb houses itself well in the macrophages of the lungs. It goes into the phagosome but doesn’t allow the phagosome to kill it. It feeds on the energy-rich lipids, and scientists argue this might keep ...

View Full Profile. Learn about our Editorial Policies. B.H. Abuaita et al., “Mitochondria-derived vesicles deliver antimicrobial reactive oxygen species to control phagosome-localized Staphylococcus ...

Introduction: Macrophage expressed gene 1 (MPEG1) is highly expressed in macrophages and other phagocytes. The gene encodes a bactericidal pore-forming protein, dubbed Perforin-2. Structural-, animal- ...