The study introduces new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment. This ...

First discovered as proteins found on synaptic vesicles and at the presynaptic plasma membrane, SNAREs are members of a family of highly conserved proteins that reside on vesicles (v-SNAREs ...

The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a paper in Nature ...

A GROUNDBREAKING study has identified rare genetic variants in the ITSN1 gene that increase Parkinson’s disease risk by up to tenfold and reveal unexpected links to autism spectrum disorder (ASD), ...

A recent study published in Psychophysiology provides new insights into how stimulating the vagus nerve through the ear might ...

Using cutting-edge genetic tools, 3D electron microscopy, and artificial intelligence, Scripps Research scientists and colleagues have uncovered key structural hallmarks of long-term memory, called an ...

Moreover, the protein's effects on endocytosis, exocytosis, and vesicle circulation are closely related to synaptic transmission. In the central nervous system, the release of calcium-dependent ...

Extracellular vesicles (EVs) have emerged as crucial mediators of intercellular communication in the brain, playing a key role in synaptic plasticity, neuroinflammation, neurogenesis, and ...

It turns out that these fatty messenger molecules are transported in fatty vesicles. This surprising discovery contrasts with how traditional messenger molecules move. Dopamine and serotonin ...

Synaptic pruning is a crucial neurodevelopmental process through which the brain refines its neural circuitry by systematically eliminating excess or weak synaptic connections. During early ...