Chronic pain, a common and debilitating condition, often leads practitioners to prescribe opioids in escalating doses.

Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid mediators exert their effects by activating two G protein-coupled receptors, ...

A new study supports the clinical utility of human nasal epithelial cultures as predictive biomarkers for cystic fibrosis CFTR modulator therapy.

Single and multi-dose studies of the small molecule TREM2 agonist VG-3927 clear early safety hurdle. Meanwhile, new findings ...

It binds both transmembrane and soluble TREM2, triggering a rise in CSF sTREM2. Single and multi-dose studies of the small ...

Leading those is galicaftor, which targets CFTR's transmembrane domain 1 (TMD1) and has completed a phase 2 study. Formed in 2019, Sionna's most recent financing was a $182 million third round ...

Canada Gairdner Awards recognize the world’s most accomplished researchers whose work is improving our understanding of human ...