But here at ESPN bowl prediction headquarters in downtown Indianapolis, we're not afraid of any circumstances. So let's get to the picks, from campus CFP sites through traditional bowls and all the way to the national title game on Jan. 20 in Atlanta.

Penn State demolished SMU in Round 1, but despite a 38-10 win, the Nittany Lions only generated 325 yards on 18 first downs. I expect Penn State to win and advance, but I’ll go under the 53 total points.

Seventh-seeded Notre Dame faces the task of replacing another key defensive player as it prepares for second-seeded Georgia and a Bulldogs' quarterback the Fighting Irish know little about.

It is the first of the CFP quarter-finals as we continue our college football odds series with a Penn State-Boise State prediction and pick.