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BMJ14h
POS0255 A RANDOMIZED, MULTICENTER, DOUBLE-BLIND, PHASE 3 STUDY COMPARING EFFICACY OF DOTINURAD AND FEBUXOSTAT FOR THE TREATMENT OF GOUT IN CHINESE SUBJECTS - Annals of the ...
Background: Gout is increasingly common disease in China. Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by selective inhibition of the urate ...
BMJ2d
Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke - Annals of the Rheumatic Diseases
Smoking is the most established environmental risk factor for developing rheumatoid arthritis (RA). 1 One hypothesis on the effect of smoking is that smoking causes citrullination of peptides and in ...
BMJ2d
Incidence, prevalence and treatment burden of polymyalgia rheumatica in the UK over two decades: a population-based study - Annals of the Rheumatic Diseases
Objective Polymyalgia rheumatica (PMR) is the most common inflammatory rheumatic disease in older people. Contemporary estimates of the incidence and prevalence are lacking, and no previous study has ...
BMJ2d
Oral sildenafil for the treatment of Raynaud’s phenomenon and digital ulcers secondary to systemic sclerosis - Annals of the Rheumatic Diseases
Raynaud’s phenomenon (RP) with or without digital ulcer formation is a significant cause of morbidity for patients with systemic sclerosis (SSc, scleroderma). Lichtenstein reported oral sildenafil as ...
BMJ3d
Treatment of primary Sjögren’s syndrome with ianalumab (VAY736) targeting B cells by BAFF receptor blockade coupled with enhanced, antibody-dependent cellular cytotoxicity
Objectives To evaluate the efficacy and safety of ianalumab (VAY736), a B cell-depleting, B cell activating factor receptor-blocking, monoclonal antibody, in patients with active primary Sjögren’s ...
BMJ10d
Head-to-head, randomised, crossover study of oral versus subcutaneous methotrexate in patients with rheumatoid arthritis: drug-exposure limitations of oral methotrexate at ...
Objective To compare the relative bioavailability, safety and tolerability of oral methotrexate (MTX) and subcutaneous (SC) MTX administered via an auto-injector (MTXAI) in patients with rheumatoid ...
BMJ16d
Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study - Annals of the Rheumatic Diseases
Background: Juvenile idiopathic arthritis (JIA) consists of a heterogeneous group of disorders with, for the most part, an unknown immunopathogenesis. Although onset and disease course differ, the ...
BMJ1mon
Non-causal association of gut microbiome on the risk of rheumatoid arthritis: a Mendelian randomisation study - Annals of the Rheumatic Diseases
I read with great interest the article by Alpizar-Rodriguez et al regarding the risk of intestinal dysbiosis, particularly Prevotella spp enrichment, in preclinical rheumatoid arthritis (RA).1 Immune ...
BMJ1mon
Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis - Annals of the Rheumatic Diseases
Objective: To test the hypothesis that dynamic load at baseline can predict radiographic disease progression in patients with medial compartment knee osteoarthritis (OA). Methods: During 1991–93 ...
BMJ1mon
The population prevalence of symptomatic radiographic foot osteoarthritis in community-dwelling older adults: cross-sectional findings from the Clinical Assessment Study of the ...
Objectives To estimate the population prevalence of symptomatic radiographic osteoarthritis (OA) affecting the 1st metatarsophalangeal joint (MTPJ), 1st and 2nd cuneometatarsal joints (CMJs), ...
BMJ1mon
Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: a multicentre ...
Methods A multicentre observational study evaluated the immunogenicity and safety of the two-dose regimen BNT162b2 mRNA vaccine in adult patients with AIIRD (n=686) compared with the general ...
BMJ2mon
Extra-articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years - Annals of the Rheumatic Diseases
Objective: To investigate the trends in incidence of extra-articular rheumatoid arthritis (ExRA) in a well defined community based cohort of patients with rheumatoid arthritis (RA), and to examine ...