>>Time Complexity: O(V + E), where V is the number of vertices (nodes) and E is the number of edges. Each node and edge is processed at most once. >>Space Complexity: O(V), as we use a stack ...

Following biomarker assessment, participants in each biomarker subgroup will be randomly assigned (1:1) to either top-down or accelerated step-up therapy, using a computer-generated algorithm (figure ...