BACKGROUND: Morbidity and mortality of heart failure with preserved ejection fraction (HFpEF) is increased in metabolic disorders. However, options for preventing and treating these prevalent outcomes ...

The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...

D-MP-SIM revolutionizes live-cell fluorescence microscopy, enabling high-speed, high-resolution imaging with reduced motion artifacts for dynamic biological research ...

Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that progresses without symptoms and is associated with significant global public health concerns. It is prevalent in 30% of ...

Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that progresses without symptoms and is associated with significant global public health concerns.

1 College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong, China 2 Shandong Provincial Key Laboratory of Zoonoses, Shandong Agricultural University, Tai'an, Shandong, China ...

Throwing new light into this domain, the NCBS scientists have proposed that Esyt possesses a C2 domain capable of binding and ...

An international study led by the University of Granada (UGR) has revealed that melatonin, known for its ability to regulate the sleep/wake cycle, can restore the composition of muscle fibers and ...

Endoplasmic reticulum stress (ERS) is the removal of unfolded and misfolded proteins and is an important mechanism for the maintenance of cellular homeostasis. ERS plays an important role in the ...

The metazoan endoplasmic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intracellular calcium storage compartment, facilitating calcium-release-dependent cellular ...