DNA repair mechanisms are crucial for the survival and growth of cells. Through a comprehensive analysis, a research team at ETH Zurich has identified numerous redundancies between the genes involved ...

Scientists have long known that more than 500 genes (out of approximately 20,000 human protein-coding genes) are crucial for DNA repair. By comprehensively analyzing the interactions of these ...

Scientists have long known that more than 500 genes (out of approximately 20,000 human protein-coding genes) are crucial for DNA repair. By comprehensively analysing the interactions of these ...

HR underlies many DNA repair processes ... fusion–bridge cycle could also be caused by any repeated non-homologous recombination process without repeated breakage and fusion 55.

DNA repair pathways are key determinants of radiotherapy response. Thus, we aimed to develop a novel DNA repair-related radiosensitivity model and to identify potential targets for enhancing ...

Despite this risk, a highly conserved feature of the meiotic program is induction of DNA double strand breaks (DSBs ... A limited subset of DSBs must engage the homologous chromosome as a ...

In human cells, the DNA double-strand breaks (DSBs) repair predominantly occurs through homologous recombination (HRR), nonhomologous end joining (NHEJ) and microhomology-mediated end joining (MMEJ) ...

Figure 1 Homologous recombination deficiency assays in epithelial ovarian cancer. Homologous recombination repair (HRR) is an important pathway for repairing DNA double-strand breaks (DSBs). In HRR, ...