Aileron Therapeutics' Phase 1b trial shows LTI-03 improved biomarkers and reduced SPD levels, indicating the potential to ...

(RTTNews) - Aileron Therapeutics, Inc. (ALRN), Wednesday announced positive topline data from the cohort 2 of Phase 1b study evaluating LTI-03 in patients with idiopathic pulmonary fibrosis (IPF).

The topline data showed ISM001-055 to have improved the forced vital capacity (FVC) of IPF patients studied 12 weeks after ...

In a small Phase IIa trial, Insilico’s generative AI-designed idiopathic pulmonary fibrosis drug improved lung function and ...

Accordingly, this study highlights the potential use of composite biomarkers mechanistic screening for compound-induced lung fibrosis. Biomarkers of pulmonary fibrosis have been identified using ...

Background: The telomere has long been regarded as a dependable biomarker for cellular senescence. The lung function can reflect the function and status of the lungs. As individuals age beyond ...

Structure Therapeutics Inc ... Thus, a patient who has idiopathic pulmonary fibrosis has scarring/damage to the lungs with no known root cause. In essence, it just comes about randomly.

Kolb has received payment from Avalyn Pharma for providing advice for the MIST trial; has received research funding for preclinical work from Boehringer Ingelheim, United Therapeutics, and Structure .

In sarcoidosis, fibrosis in affected organs, especially the lungs and heart, accounts for most of the long ... matrix metalloproteinases and other markers of tissue disruption in pulmonary, cardiac ...

AN INSIGHTFUL session on the future of lung ... fibrosis (CF) transmembrane conductance regulator (CFTR) modulators in a population of patients with a single Phe508del allele variant, a frequent ...

Mike, who used to work as a delivery driver, was experiencing breathlessness for several months before doctors discovered pulmonary fibrosis — which causes scarring in the lungs — this May.

This is the definition of the condition according to Mayo Clinic. The experts said: Pulmonary fibrosis is a lung disease that occurs when lung tissue becomes damaged and scarred. This thickened ...