Excessive activity of 'osteoclasts' or bone-absorbing cells leads to bone loss. Targeting osteoclast differentiation is therefore, a potential therapeutic strategy.

In a new study, researchers from Japan reveal that iSN40 suppresses osteoclast differentiation and bone matrix resorption, offering a potential therapeutic approach for osteoporosis by restoring ...

A mouse study shows that dietary oleic acid, a key Mediterranean diet component, protects against age-related bone and ...

A representative micrograph of osteoclast differentiation and activity in response to irradiation with blue light. Numerous small pits formed on the bone-like substrate in the half of the well ...

During osteoclast differentiation, Ctdnep1 expression remains consistent, yet its depletion results in heightened osteoclast formation and activity. Mechanistically, Ctdnep1 demonstrates a ...

Additionally, Ctdnep1 knockdown led to an increase in the expression of crucial differentiation markers including 'Nfatc1', a RANKL-induced master transcription factor for osteoclast differentiation.

The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that regulates both osteoclast and osteoblast differentiation can aid the ...

He referenced preclinical data, mostly about first-generation drugs, that indicated GLP-1 agonists may promote bone formation by increasing osteoblast differentiation and survival while reducing ...