Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements.

The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that ...

Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements.

Osteoblasts/stromal cells produce osteoclast differentiation factor (ODF) or stromal osteoclast forming activity (SOFA) as a membrane-associated factor in response to osteotropic factors ...

Osteoclasts derive from a myeloid progenitor that gives rise to both the monocyte-macrophage lineage and the osteoclast lineage. A mononuclear pre-osteoclast exists that expresses both TRAP and CTR.

Additionally, in vitro studies detected that miR-335-3p is important for osteoclast differentiation, with its direct targeting site in FOS. Further studies demonstrated FOS was upregulated in CUMS ...