The team was led by Dr. Yong Ryoul Yang of the Aging Convergence Research Group at the Korea Research Institute of Bioscience and Biotechnology (KRIBB, President: Seok-Yoon Kwon) and Professor ...

Osteoporosis, a condition marked by reduced bone mass and structural deterioration, continues to be a major public health concern, especially as global populations age. Excessive osteoclast formation ...

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts.

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts.

Mechanistically, Acod1 suppressed osteoclast differentiation by inhibiting succinate dehydrogenase-dependent production of reactive oxygen species and Hif1α-mediated induction of aerobic glycolysis.

Thus, 55% of the macrophages in aneurysmal tissue underwent osteoclastogenic differentiation. Taken together, these results demonstrate the significant activity of osteoclast-like cells in human and ...

Osteoclasts are bone resorbing cells that are essential to maintain skeletal integrity and function. While many of the growth factors and molecular signals that govern osteoclastogenesis are well ...

Excessive activity of 'osteoclasts' or bone-absorbing cells leads to bone loss. Targeting osteoclast differentiation is therefore, a potential therapeutic strategy.

Their structures were determined by the analysis of spectroscopic data, quantum chemical calculations, and X-ray diffraction analyses. Peniditerpenoid A (1) inhibited lipopolysaccharide-induced NF-κB ...

Bone remodeling is a complex process involving the coordinated actions of osteoblasts and osteoclasts to maintain bone homeostasis. While the influence of osteoblasts on osteoclast differentiation is ...

A representative micrograph of osteoclast differentiation and activity in response to irradiation with blue light. Numerous small pits formed on the bone-like substrate in the half of the well ...