Targeting osteoclast differentiation is therefore, a potential therapeutic strategy. In a new study, researchers have discovered a novel role of the Ctdnep1 phosphatase in suppressing osteoclast ...

"We were pleased to see that iSN40 not only promoted bone formation by osteoblasts but also inhibited osteoclast differentiation, which could have a major impact on preventing bone loss in ...

The article, “Development of an optogenetics tool, Opto‑RANK, for control of osteoclast differentiation using blue light,” was published in Scientific Reports at DOI: 10.1038/s41598-024 ...

During osteoclast differentiation, Ctdnep1 expression remains consistent, yet its depletion results in heightened osteoclast formation and activity. Mechanistically, Ctdnep1 demonstrates a ...

The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that regulates both osteoclast and osteoblast differentiation can aid the ...

Osteoclasts arise from the differentiation of macrophages or monocytes, which are types of immune cells. Suppressing osteoclast differentiation can, therefore, serve as a therapeutic strategy to ...