“In particular, whole-cell patch clamp revolutionized classical electrophysiology,” remarked Neher. Subsequently, the groups developed two other configurations that could be performed once they ...

An Introductory Guide to Patch Clamp Electrophysiology, for his tips on forming that perfect seal. His advice follows. When you place the micropipette in its holder, you can easily make electrical ...

Research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 (HDAC5) limits the expression of the gene Scn4b, regulating neuronal activity and ...

We use techniques and models including optical mapping of ex vivo hearts, conventional and fluorescence-coupled electrophysiology (e.g. patch clamp, TEVC, voltage clamp fluorimetry, LRET), molecular ...

“We use a technique called patch clamp electrophysiology, which is very cool because I get to see life happen right before my eyes,” she says. "I get to watch neurons fire action potentials and single ...