"Rather than letting the bacteria continue to replicate, the mitochondria sense bacterial metabolites in the phagosome and trigger the neutrophil to undergo NETosis—an antimicrobial cell death ...

The approach pioneered by Guan's lab uses engineered particles with fluorescent markers that allow researchers to observe their breakdown and formation into phagosome-derived vesicles, or PDVs.

“Rather than letting the bacteria continue to replicate, the mitochondria sense bacterial metabolites in the phagosome and trigger the neutrophil to undergo NETosis—an antimicrobial cell death ...

Researchers at the FAMU-FSU College of Engineering have developed a new method for studying protein degradation in immune cells, using engineered microparticles that offer a more precise and ...

M.tb houses itself well in the macrophages of the lungs. It goes into the phagosome but doesn’t allow the phagosome to kill it. It feeds on the energy-rich lipids, and scientists argue this might keep ...

Several students from the Southern Arkansas University College of Science and Engineering took part in the 108th annual ...

These include altering phagosome maturation, resisting oxidative stress, and forming protective niches within host cells. The host initially detects these pathogens through pattern recognition ...

This study provides proof-of-principle data for the use of trained immunity to modulate macrophage interactions with tumours. The study makes a valuable contribution to the field of trained immunity.

Background: Phosphatidylcholine (PC) is a major lipid of the gastrointestinal mucus layer. We recently showed that mucus from patients suffering from ulcerative colitis has low levels of PC ...