Neutrophils' mitochondrial sensing disrupted in lupus patients, study finds
Assistant Professor Andrew Monteith's lab in the Department of Microbiology is documenting how key immune cells detect ...
World TB Day: Why Tuberculosis manifests in many different ways
TB is a result of complex interplay between M.tb and human immune cells. While current research can explain why TB manifests ...
Frontiers2mon
Two-pore channel regulators - Who is in control?
In sum, recent evidence suggests that TPCs are involved in a multitude of immune cell functions, reportedly regulating inflammatory mediator release, phagosome resolution, phagocytosis, granzyme B ...
usm4mon
Dr. Ramesh Rijal
In a first line of research, we study how bacterial polyP modulates macrophage functions, including phagosome acidification, lysosome activity, autophagy, and cell polarization, facilitating bacterial ...
eLife4y
Bacterial symbiont subpopulations have different roles in a deep-sea symbiosis
The hydrothermal vent tubeworm Riftia pachyptila hosts a single 16S rRNA phylotype of intracellular sulfur-oxidizing symbionts, which vary considerably in cell morphology and exhibit a remarkable ...
eLife5y
Dynamic post-translational modification profiling of Mycobacterium tuberculosis-infected primary macrophages
Macrophages are highly plastic cells with critical roles in immunity, cancer, and tissue homeostasis, but how these distinct cellular fates are triggered by environmental cues is poorly understood. To ...
Frontiers6y
Neutrophil Effector Functions Are Not Impaired in Duffy Antigen Receptor for Chemokines (DARC)-Null Black South Africans
HIV-1 chronically infected Zulu/Xhosa black individuals in Durban, South Africa. We hypothesized that neutrophil effector mechanisms including phagosome maturation, production of reactive oxygen ...