Could stem cells step in to replace lost neurons in Parkinson’s disease? In three Phase 1 clinical trials, scientists tested lab-grown dopaminergic cells in small cohorts to assess safety and look for ...

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This transgenic model of tauopathy expresses MAPT with the P301S mutation, which is associated with autosomal-dominant disease in humans. The hTau.P301S model recapitulates several molecular, cellular ...

This dataset organizes published data on fluid biomarkers for Alzheimer’s disease and other related conditions. Measurements of biomarker levels from cerebrospinal fluid and blood in non-AD conditions ...

In the Alzheimer’s brain, microglia diversify into several activation states. What controls this specialization? In a preprint posted to bioRxiv on October 13, scientists led by Martin Kampmann at the ...

Retrotransposons are evolutionarily ancient genes that “jump” around the human genome leaving a slew of repeat nucleotide sequences in their wake. These repeats can disturb normal gene function.

Synonyms: High-copy SOD1-G93A, B6SJL.SOD1-G93A, Tg(hSOD1-G93A)1GUR mice, Gurney mice ...

In a new proteomics extravaganza, scientists have unearthed groups of proteins that appear to be at the heart of Alzheimer’s disease pathogenesis. As described in Cell on September 25, scientists led ...

This widely used tauopathy model was developed at the University of Pennsylvania School of Medicine by Virginia Lee, John Trojanowski, and colleagues. As first reported in 2007 on a mixed background, ...

Multiple streams of evidence converge on a central role for lipid metabolism in neurodegenerative diseases. With an apolipoprotein as its top genetic risk factor, sporadic Alzheimer’s disease is no ...

The digital microscopy platform for neurodegenerative diseases is being developed by Jochen Herms and Sigrun Roeber at the Center for Neuropathology and Prion Research of Ludwig Maximilian University, ...

Scientists have uncovered a potential new mechanism whereby α-synuclein pathology spreads. Like black holes, large densities of α-synuclein pull in surrounding matter. Among the victims trapped in ...