Throughout the course of multiple sclerosis, gradually progressive neurologic impairment can occur, which has been called ...

Tolebrutinib is an oral, brain-penetrant, and bioactive Bruton’s tyrosine kinase inhibitor that modulates peripheral ...

The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific antigen (PSA) has a high rate for false positive results. Genomewide association studies have ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

The National Academy of Medicine and the Journal have partnered to create this series on issues important to health and medicine.

Autoimmune generalized myasthenia gravis is a disease that manifests with fluctuating muscle weakness. Inebilizumab is a monoclonal antibody that depletes CD19+ B cells, which are central to ...

Endovascular thrombectomy is highly effective for acute ischemic stroke due to large-vessel occlusion, but its efficacy and safety for stroke due to medium-vessel occlusion remain unclear.

During the American Revolution, more than in any subsequent U.S. war, doctors played critical roles beyond their medical functions. A key leader at the outset of the war was Dr. Joseph Warren.

Endovascular treatment is safe and effective in acute ischemic stroke caused by large-vessel occlusion; however, its benefit for occlusion of medium or distal vessels is unclear. New research ...